Alzheimer disease


We were unfortunately unable to download the information for this disease from OMIM.

Prevalence of clinical parameters (%)

List of symptoms

Symptom/sign Organ system Percent affected Pubmed id Added on(yyyy-mm-dd)
Dementia nervous 100 % 15534185 2013-08-22
Cerebral atrophy nervous 100 % 23303849 2016-12-22
Myoclonus nervous 61 % 15534185 2013-08-22
Limb dyspraxia nervous 44 % 15534185 2013-08-22
Anosmia nervous 23 % 16170073 2013-11-04
Hyperactive reflexes nervous 22 % 15534185 2013-08-22
Late visual disorientation nervous 17 % 15534185 2013-08-22
Seizures nervous 17 % 15534185 2013-08-22
Gait disturbances nervous 17 % 15534185 2013-08-22

List of references:

The natural history of Alzheimer disease: a longitudinal presymptomatic and symptomatic study of a familial cohort.
Alison K Godbolt, Lisa Cipolotti, Hilary Watt, Nick C Fox, John C Janssen, Martin N Rossor,

Knowledge of the evolution of cognitive deficits in Alzheimer disease is important for our understanding of disease progression. Previous reports, however, have either lacked detail or have not covered the presymptomatic stages.

Archives of neurology - Nov 2004

Cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration.
Kelvin K Leung, Jonathan W Bartlett, Josephine Barnes, Emily N Manning, Sebastien Ourselin, Nick C Fox, ,

To quantify the regional and global cerebral atrophy rates and assess acceleration rates in healthy controls, subjects with mild cognitive impairment (MCI), and subjects with mild Alzheimer disease (AD).

Neurology - Feb 2013

Anosmia is very common in the Lewy body variant of Alzheimer's disease.
J M Olichney, C Murphy, C R Hofstetter, K Foster, L A Hansen, L J Thal, R Katzman,

Olfactory abnormalities are reported in Alzheimer's disease and Parkinson's disease. Anosmia appears to be common in dementia with Lewy bodies but not in pure Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - Oct 2005